RISAFloor ES allows you to model concrete slabs of any thickness. However, there might be sections of the building that require a thicker slab. The icon is shown below and it will allow you to draw a Polygon or Rectangular shape.
You can use this tool to change the thickness anywhere in the slab.
The thickened region will show in the Full Model view and the FEA plates will be thickened in that region. Also all the reinforcement calculations will take into account this thickened area.